The epigenetic clock

It is remarkable that aging is associated with highly reproducible epigenetic modifications. Using a broad range of DNA-methylation profiles we elaborated an Epigenetic-Aging-Signature based on three specific CpG sites in the genome. DNA-methylation levels of these sites can be integrated into a mathematical model to predict the donor age with a mean average deviation from chronological age of only about 5 years. The deviation can at least partly be attributed to life-style parameters, gender, and disease. Thus, the Epigenetic-Aging-Signature seems to be indicative for the biological age of blood.


Area of application

Cygenia will analyze the DNA methylation patterns at three specific genomic regions in your samples and thereby estimate donor age. In comparison to the “real” chronological age it is possible to identify threats that affect epigenetic aging. At the moment this service is only provided for basic research, although we understand that you might be interested in testing your own biological age. Concurrently, Cygenia only addresses scientists and physicians who want to better understand the impact of specific parameters on biological age. In comparison to other methods, such as telomere length measurements, the precision of epigenetic age predications is higher. 


Relevant Literature

Patent application: 2012; EP12185698.3