Epigenetic-Aging-Signature for Blood
Biological aging is reflected by highly reproducible DNA-methylation changes at specific sites in the genome. Biological age can be estimated based on DNA-methylation levels at three specific CpG sides in blood samples.
Epigenetic-Aging-Signature for Buccal Swabs
Alternatively, genomic DNA can be harvested non-invasively from the inside of a person's cheek with buccal swabs. Cygenia provides new models to estimate biological age with buccal swabs. The precision of age predictions is further increased with a Buccal-Cell-Signature which estimates the percentage of buccal epithelial cells versus leukocytes.
Epigenetic Aging in Mice
Mice are often used for intervention studies to determine how treatment or specific genetic background impact on biological aging. Cygenia provides a new epigenetic signature to estimate the biological age of mice.