Non-invasive analysis of biological age

Age-associated DNA-methylation changes can not only be tracked in DNA of blood - but also in buccal swabs. Using a broad range of DNA-methylation profiles we elaborated an Epigenetic-Aging-Signature based on three specific CpG sites in the genome. DNA-methylation levels at these three sites can be integrated into a mathematical model to predict the donor age with a mean average deviation from chronological age of only about 5 years. For buccal swabs it is important to adjust the mathematical models. Furthermore, the precision can be further enhanced by a "Buccal-Cell-Signature", which determines the percentage of buccal epithelial cells vs. leukocytes.

Read more about the Buccal-Cell-Signature

 

Area of application

Cygenia will analyze the DNA-methylation patterns at three specific genomic regions and thereby estimate donor age. In comparison to the “real” chronological age it is then possible to identify threats that affect epigenetic aging. At the moment this new service is only provided for basic research, although we understand that you might be interested in testing your own biological age. Concurrently, Cygenia only addresses scientists and physicians who want to better understand the impact of specific parameters on biological age. We can send you buccal swabs that you can use for sample collection and shipment by mail. Cygenia will then perform DNA isolation. Alternatively, you can already send genomic DNA.

 

Relevant Literature

Weidner C.I. et al. Aging of blood can be tracked by DNA methylation changes at just three CpG sites. Genome Biology, 2014; 15:R24.

 
Patent application:
DE 10 2016 109 291.6  (Buccal-Cell-Signature)
2012; EP12185698.3 (Epigenetic-Aging-Signature)