About Epigenetics

Cygenia provides service for epigenetic analysis. Epigenetic processes - such as modifications in the DNA methylation pattern - are dynamic modifications on the DNA strands that govern the transcriptional potential of genes and determine cellular development.

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Epigenetic diagnostics of disease

Particularly malignant diseases are associated with specific changes in the DNA-methylation pattern. Epigenetic diagnostics are therefore a viable alternative to further strengthen diagnostics of diseases – such as leukemia.

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Prediction of biological age

There is a growing perception that aging is associated with highly reproducible DNA-methylation changes at specific sites in the genome. Cygenia provides methods to estimate “biological age” based on three genomic regions to gain further insight into parameters that impact on aging.

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Quality control of cell cultures

Cells in culture maintain epigentic characteristics of their tissue of origin, their cell type, and culture conditions. Thus, the DNA-methyation pattern provides great potential for quality control of cells - e.g. with regard to replicative senescence or differentiation potential.

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Study design and bioinformatics

Your research may require a new assay design or epigenetic profiling. For such experiments detailed planning is a prerequisite. Furthermore, experience in bioinformatics is necessary – particularly when working with genome wide profiles and deep sequencing data.

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